![Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S104620231530181X-gr2.jpg)
Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect
Detection of targeted DSB formation at AAVS1 in HeLa cells. a Target... | Download Scientific Diagram
![Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S104620231530181X-gr1.jpg)
Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect
![Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors: Molecular Therapy Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors: Molecular Therapy](https://www.cell.com/cms/attachment/12b4bcfd-3bef-4b14-99b4-eb35e9e950c4/fx1_lrg.jpg)
Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors: Molecular Therapy
![Site-specific integration of adeno-associated virus involves partial duplication of the target locus | PNAS Site-specific integration of adeno-associated virus involves partial duplication of the target locus | PNAS](https://www.pnas.org/cms/10.1073/pnas.0806821106/asset/8cf3ff58-3b74-4a47-94d8-e2243bbef600/assets/graphic/zpq9990976730006.jpeg)
Site-specific integration of adeno-associated virus involves partial duplication of the target locus | PNAS
![Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S104620231530181X-gr3.jpg)
Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives - ScienceDirect
![Quantification of transgene expression in GSH AAVS1 with a novel CRISPR/Cas9-based approach reveals high transcriptional variation: Molecular Therapy - Methods & Clinical Development Quantification of transgene expression in GSH AAVS1 with a novel CRISPR/Cas9-based approach reveals high transcriptional variation: Molecular Therapy - Methods & Clinical Development](https://www.cell.com/cms/attachment/60d4043d-d0b9-4d06-af20-f75553f034de/gr1_lrg.jpg)
Quantification of transgene expression in GSH AAVS1 with a novel CRISPR/Cas9-based approach reveals high transcriptional variation: Molecular Therapy - Methods & Clinical Development
![Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector‐mediated zinc finger nuclease expression in human‐induced pluripotent stem cells - Tay - 2013 - The Journal of Gene Medicine - Wiley Online Library Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector‐mediated zinc finger nuclease expression in human‐induced pluripotent stem cells - Tay - 2013 - The Journal of Gene Medicine - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/6b105c15-6089-455b-98bf-5d91f74d0f5d/jgm2745-fig-0001-m.jpg)
Targeted transgene insertion into the AAVS1 locus driven by baculoviral vector‐mediated zinc finger nuclease expression in human‐induced pluripotent stem cells - Tay - 2013 - The Journal of Gene Medicine - Wiley Online Library
![Detailed design of PITCh-TG in human AAVS1 locus. Black lines indicate... | Download Scientific Diagram Detailed design of PITCh-TG in human AAVS1 locus. Black lines indicate... | Download Scientific Diagram](https://www.researchgate.net/publication/316574925/figure/fig1/AS:565785958338560@1511905292948/Detailed-design-of-PITCh-TG-in-human-AAVS1-locus-Black-lines-indicate-the-target.png)
Detailed design of PITCh-TG in human AAVS1 locus. Black lines indicate... | Download Scientific Diagram
Identification of the safe harbor locus, AAVS1, from porcine genome and site-specific integration of recombinase-mediated casset
![A) Nucleotide sequence alignment of the human, mouse, and monkey AAVS1... | Download Scientific Diagram A) Nucleotide sequence alignment of the human, mouse, and monkey AAVS1... | Download Scientific Diagram](https://www.researchgate.net/publication/8428486/figure/fig1/AS:281054976987136@1444020136037/A-Nucleotide-sequence-alignment-of-the-human-mouse-and-monkey-AAVS1-sequences.png)
A) Nucleotide sequence alignment of the human, mouse, and monkey AAVS1... | Download Scientific Diagram
![Quantification of transgene expression in GSH AAVS1 with a novel CRISPR/Cas9-based approach reveals high transcriptional variation: Molecular Therapy - Methods & Clinical Development Quantification of transgene expression in GSH AAVS1 with a novel CRISPR/Cas9-based approach reveals high transcriptional variation: Molecular Therapy - Methods & Clinical Development](https://www.cell.com/cms/attachment/f564367d-63a5-4e89-988f-011f690dcffd/fx1_lrg.jpg)